Pre-targeting with ultra-small nanoparticles: boron carbon dots as drug candidates for boron neutron capture therapy
نویسندگان
چکیده
Tetrazine-functionalised boron-rich carbon dots show fast clearance and enhanced tumour accumulation under pre-targeting conditions, as demonstrated using positron emission tomography.
منابع مشابه
Boron Neutron Capture Therapy
A project aimed at the development of an accelerator facility devoted to Boron Neutron Capture Therapy (BNCT) is ongoing at the National Atomic Energy Commission of Argentina [1]. In a first stage of development, the accelerator will be capable of delivering proton or deuteron beams of 30 mA at about 1.4 MeV which is suitable for neutron production through the 9Be(d,n) reaction. In this context...
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Preclinical studies for boron neutron capture therapy (BNCT) using epithermal neutrons are ongoing at several laboratories. The absorbed dose in tumor cells is a function of the thermal neutron flux at depth, the microscopic boron concentration, and the size of the cell. Dosimetry is therefore complicated by the admixture of thermal, epithermal, and fast neutrons, plus gamma rays, and the array...
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ژورنال
عنوان ژورنال: Journal of Materials Chemistry B
سال: 2021
ISSN: ['2050-7518', '2050-750X']
DOI: https://doi.org/10.1039/d0tb01880e